naturesQue Regeneration line – The essence of nature in e

The naturesQue regenerative materials combine the strengths of the natural origin of the material with scientific and clinical expertise for tissue regeneration.

naturesQue regenerative materials

In the area of bone substitute materials, naturesQue has two products:

an innovative xenohybrid bone substitute material derived from bovine bone, coated with a co-polymer mix and collagen fragments and
an established xenogeneic bone substitute material derived from porcine cancellous bone

In the area of collagen products, naturesQue has three products:

a stable porcine barrier membrane to protect the augmentation material,
microfibrillar bovine collagen that forms a highly viscous gel after exudate uptake and has intrinsic hemostatic properties,
a porcine collagen fleece that retains its 3D structure and stabilizes the blood clot

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Xenogeneic bone substitute materials

The exceptional ability of bone tissue to regenerate is fascinating. This complex tissue heals almost without forming scars and recovers its original structure and functionality. The jumping distance that osteoblasts can bridge and the dimensions of the critical size defects that are used in study models impressively demonstrate not the limits but rather the potential of bone for regeneration.

The essential factors for bone regeneration are an adequate blood supply, mechanical support in the form of a guiding structure, and rest. Bone substitute materials are used for the regeneration of bone where the human body is not able to heal the bones itself. Along with the requirements 10 for an ideal bone substitute material, it is a generally accepted paradigm that bone substitute materials should mimic human cancellous bone as closely as possible [1].

The natural origin of xenogeneic bone substitute material gives it an optimal design. Porosity, pore distribution, and pore size correspond largely to those of human bone and are suitable to achieve bone formation, maturation, and remodeling. However, the purification of animal bone leads to a reduction in mechanical strength and biological potency, because cells and proteins have to be removed to eliminate the risk of transmitting disease and of rejection.

The xenohybrid bone substitute material naturesQue SemOss B is one of the new generation of regenerative nature-based regeneration materials. The combination of different material classes compensates for the limitations of the individual elements and amplifies their positive properties.
The established inorganic bone mineral naturesQue MaxOss P is obtained from porcine cancellous bone. The matrix is very porous and also provides ample space for new bone apposition and the remodeling processes during bone maturation.

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Properties of xenogeneic bone substitue materials	Function and use in bone regeneration

Porous, interconnecting structure with adequate pore size (≥ 100 µm)	Diffusion and migration of cells, nutrients, and exchange of metabolic products throughout the entire material
Surface characteristics	Allows cell adhesion, migration, and proliferation of osteoblasts
Adequate mechanical strength and elasticity	Enables the absorption of applied force into the surrounding hard and soft tissues in non-self-retaining defects
Controlled biodegradation	Resorption during the tissue remodeling process with the volume being retained to allow bony ingrowth in the defect

Xenogeneic collagen products

Collagen is highly conserved throughout evolution, meaning that xenogeneic collagen is very similar to that of humans and generally tolerated exceptionally well. Along with the donor species and the tissue used, there are a number of other factors that are critical for the properties of collagenous medical devices, with the procedures used during harvesting playing a role in which characteristics are highlighted in the product. Modern medicine is inconceivable without collagens and their use is one of many important therapeutic concepts.

Fibrillar collagens are proteins with a high tensile strength that are essential for structure formation and biomechanics in tissues. Collagen has positive effects in healing. In the early phases, it has intrinsic hemostatic properties while also being able to absorb large volumes of fluid, thus helping to create a moist wound environment that encourages healing [2].

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Properties of xenogeneic collagens	Function and use in regeneration

Conserved throughout evolution	Significant similarity between human and xenogeneic collagens leads to outstanding tolerance of xenogeneic collagens
Intrinsic hemostatic properties	collagen can act as a substrate for platelet binding[3]
Ability to integrate into the surrounding tissue	Thanks to the good tolerance of xenogeneic collagens, they are generally integrated into the surrounding tissue and broken down by physiological catabolic processes.
Adaptable properties resulting from the processing method	Tear-resistant fibrillar collagen can be processed to produce a number of sophisticated medical devices with different properties – including: Non-adherent thin barrier membranes Porous collagen sponges having intrinsic hemostatic properties to control minor bleeding In fibrillar form as an absorbent agent in the wound area because large volumes of fluid can be absorbed

Universal solutions will never satisfy all requirements

For years we at BEGO Implant Systems have implemented the system concept in the area of implant dentistry. For this reason, BEGO Implant Systems works to-gether with partners in certain areas so that we are always able to offer products at the peak of dental technology. Our procedure in the area of regeneration materials is called OWN Brand Dis-tribution Label – an expression for us of partnerships that are full of synergies between manufacturers with established expertise in innovative regenerative biomaterials and our expertise as a developer, manufacturer, and distributor of dental implants. BEGO Implant Systems will stake out a stronger position in the area of regenera-tive materials in implant dentistry with the naturesQue product line because we perfectly combine the established with the innovative.

The framework conditions and rules of the game in the area of medical devices
Our naturesQue product line is synonymous with modern and successful regenerative materials. In light of increasing regulatory requirements, this is simply not enough. For BEGO Implant Systems and our partners this means that our approach and the implementation of regulatory frameworks have to be implemented conscientiously, precisely, reliably, and practicably.

Haugen HJ, Lyngstadaas SP, Rossi F, Perale G. Bone grafts: which is the ideal biomaterial? J Clin Periodontol. (2019);46 Suppl 21:92-102
Kujath P, Michelsen A. Wounds – From Physiology to Wound Dressing. Deutsches Ärzteblatt International Dtsch Arztebl Int (2008) 105;13: 239–48
D. Rothamel, F. Schwarz, V. Stoldt, M. Herten, C. Kotthaus, J. Becker. In-vitro-Testung der Thrombozytenaggregation an zahnärztlich verwendeten kollagenen Hämostyptika. Mund- Kiefer- und Gesichtschirurgie 10(3):148-54 · May 2006