naturesQue ColTect P – Xenogeneic porcine barrier membra

Assuming that the clinical requirements for a barrier membrane are satisfied, individual preferences for the handling properties play a major role in the choice of collagen membranes. The easy handling of naturesQue ColTect P enables diverse applications in therapeutic concepts that include the use of regenerative measures.

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Documented patient information on bone reconstruction

Structure, design, and stability

naturesQue ColTect P is manufactured from purified collagen-rich tissue. Using a gentle method, the collagen is minimally crosslinked to give the membrane a predictable resorption profile with maximum tissue tolerability. A crosslinked structure prevents premature enzymatic cleavage of the collagen fibers and gives
naturesQue ColTect P a reproducible and reliable barrier function that is adapted to the time profile of bone healing.

This produces a highly versatile and strong membrane with comfortable handling properties.
naturesQue ColTect P is made up of a layer of intact collagen fibers. The membrane is not side specific.

BIS_naturesQues_ColTect-P_5_Membran_300x_gekippt-45 — Scanning electron microscopy image of
naturesQue ColTect P.

Requirements profile for a collagen membrane

Collagen membranes alone do not have sufficient mechanical stability to shape and protect defect contours. For this reason naturesQue ColTect P is used together with bone substitute materials such as naturesQue SemOss B or naturesQue MaxOss P.

The use of bone substitute materials creates a volumizing framework in the defect space that is used by the osteoblasts as a substrate for bone deposition.

A barrier membrane protects the spaces in the bone defect and prevents the ingrowth of soft tissues. The job of the membrane is to establish and maintain a barrier that is permeable to nutrients between the bone and soft tissue. The membrane also stabilizes the augmentation material by covering the bone defect. The barrier function of naturesQue ColTect P lasts about 3 months, which is sufficiently long to ensure adequate bone healing.

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Handling and feel

The naturesQue ColTect P membrane can be applied wet or dry. The membrane is cut to size so that the piece overlaps the margin of the defect by about 2 mm. When dry, naturesQue ColTect P is a sturdy, stable membrane. Wetting the membrane with saline or blood makes naturesQue ColTect P flexible, enabling it to be adapted to the defect contours.

It is not usually necessary to fix naturesQue ColTect P because the membrane can be easily wetted and adheres to the bone walls. Nevertheless, naturesQue ColTect P can be repositioned should this be necessary. If needed, naturesQue ColTect P can be sutured or fixed with pins.

naturesQue ColTect P put into context

Origin

Porcine peritoneum

Composition

Intact collagen fibers
Stabilized by reliable minimal crosslinking

Processing

Collagen-rich peritoneum
Cleaning and removal of non-collagenous proteins
Stabilization of the collagen fibers using minimal crosslinking
Washing, rinsing, and drying
Measurement, packaging, and sterilization
Quality Control

Application

Remove with sterile instruments
Processed wet or dry
Adapt to the size of the defect, overlapping by about 2 mm
Closed healing is recommended
No specific side for positioning
Can be repositioned

Consistency/Feel

Dry: Stable and rigid, sturdy
Wet: Can be draped, sturdy, adhesive, not sticky
Does not stretch
Tear resistant

Resorption

Resorption time between 12 and 16 weeks

Publikationen naturesQue ColTect P

Guarnieri R, Stefanelli L, De Angelis F, Mencio F, Pompa G, Di Carlo S. Extraction Socket Preservation Using Porcine-Derived Collagen Membrane Alone or Associated with Porcine-Derived Bone. Clinical Results of Randomized Controlled Study. Journal of Oral & Maxillofacial Research. 2017;8(3):e5,1-9**
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Guarnieri R, DeVilliers P, Grande M, Stefanelli LV, Di Carlo S, Pompa G. Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovine–and porcine-derived bone: a comparative case report in humans. Regenerative Biomaterials. 2017;125-128**

Guarnieri R, Testarelli L, Stefanelli L, De Angelis F, Mencio F, Pompa G, Di Carlo S. Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis. Journal of Oral & Maxillofacial Research. 2017;8(4):1-9**
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Li ST, Yuen D, Martin D, Lee NS. New Porcine Collagen Membrane to Bio-Gide^®A Comparative Study of a New Porcine Collagen Membrane to Bio-Gide^®. Science, Technology, Innovation. 2015;1-5*
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*MatrixFlex is a trade name from Collagen Matrix Inc. and identical to naturesQue ColTect P
**Mem-Lok Pliable is a trade name from BioHorizons and identical to naturesQue ColTect P